Nicholson HJ III, Sakhrani N, Rogot J, Lee AJ, Ojediran IG, Sharma R, Chahine NO, Ateshian GA, Shah RP, Hung CT. Effect of Blood on Synovial Joint Tissues: Potential Role of Ferroptosis. Applied Sciences. 2024. link

Lee AJ, Gangi LR, Zandkarimi F, Stockwell BR, Hung CT. Red blood cell exposure increases chondrocyte susceptibility to oxidative stress following hemarthrosis. Osteoarthritis Cartilage. 2023. link

Kenawy HM, Marshall SL, Rogot J, Lee AJ, Hung CT, Chahine NO. Blocking toll-like receptor 4 mitigates static loading induced pro-inflammatory expression in intervertebral disc motion segments. Journal of Biomechanics. 2023. link

Pellicore MJ, Gangi LR, Murphy LA, Lee AJ, Jacobsen T, Kenawy HM, Shah RP, Chahine NO, Ateshian GA, Hung CT. Toward Defining The Role Of The Synovium In Mitigating Normal Articular Cartilage Wear And Tear. Journal of Biomechanics. 2023. link

Sakhrani N, Stefani RM, Setti S, Cadossi R, Ateshian GA, Hung CT. Pulsed Electromagnetic Field Therapy and Direct Current Electric Field Modulation Promote the Migration of Fibroblast-like Synoviocytes to Accelerate Cartilage Repair In Vitro. Applied Sciences. 2022. link

Kroupa KR, Gangi LR, Zimmerman BK, Hung CT, Ateshian GA. Superficial zone chondrocytes can get compacted under physiological loading: A multiscale finite element analysis. Acta Biomaterialia. 2022 Oct 12;S1742-7061(22)00668-7.

doi: 10.1016/j.actbio.2022.10.013. link

Sakhrani N, Lee AJ, Murphy LA, Kenawy HM, Visco CJ, Ateshian GA, Shah RP, Hung CT. Toward Development of a Diabetic Synovium Culture Model. Frontiers in Bioengineering and Biotechnology. 2022. doi: 10.3389/fbioe.2022.825046. link

Hung CT, Racine-Avila J, Pellicore MJ, Aaron R. Biophysical Modulation of Mesenchymal Stem Cell Differentiation in the Context of Skeletal Repair. IJMS. 2022. https://doi.org/10.3390/ijms23073919. link

Gangi LR*, Petersen CA*, Oungoulian SR, Estell EG, Durney KM, Suh JT, Ateshian GA, Hung CT. A Friction Testing-Bioreactor Device for Study of Synovial Joint Biomechanics, Mechanobiology, and Physical Regulation. J. Vis. Exp. 2022 Jun 2;(184). doi: 10.3791/63880. link (*contributed equally)

Lee AJ, Mahoney CM, Cai CC, et al. Sustained Delivery of SB-431542, a Type I Transforming Growth Factor Beta-1 Receptor Inhibitor, to Prevent Arthrofibrosis. Tissue Eng Part A. 2021. doi:10.1089/ten.TEA.2021.0029. link

Estell EG, Murphy LA, Gangi LR, Shah RP, Ateshian GA, Hung CT. Attachment of cartilage wear particles to the synovium negatively impacts friction properties, Journal of Biomechanics. 2021. doi: 10.1016/j.jbiomech.2021.110668. link

Stefani RM, Barbosa S, Tan AR, Setti S, Stoker AM, Ateshian GA, Cadossi R, Vunjak-Novakovic G, Aaron RK, Cook JL, Bulinski JC, Hung CT. Pulsed Electromagnetic Fields Promote Repair of Focal Articular Cartilage Defects with Engineered Osteochondral Constructs. Biotechnology and Bioengineering. 2020. doi:10.1002/bit.27287. link

Stefani RM, Lee AJ, Tan AR, Durney KM, Halder SS, Stoker AM, Ateshian GA, Guo XE, Marra KG, Cook JL, Hung CT. Sustained Low-dose Dexamethasone Delivery Via a PLGA Microsphere-embedded Agarose Implant for Enhanced Osteochondral Repair. Acta Biomater. 2020;102:326-340. doi:10.1016/j.actbio.2019.11.052. link

Estell EG, Silverstein AM, Stefani RM, Lee AJ, Murphy LA, Shah RP, Ateshian GA, Hung CT. Cartilage Wear Particles Induce an Inflammatory Response Similar to Cytokines in Human Fibroblast‐like Synoviocytes. J Orthop Res 2019;37(9):1979-1987. doi:10.1002/jor.24340. link

Stefani RM, Halder SS, Estell EG, Lee AJ, Silverstein AM, Sobczak E, Chahine NO, Ateshian GA, Shah RP, Hung CT. A Functional Tissue Engineered Synovium Model to Study Osteoarthritis Progression and Treatment. Tissue Eng Part A. 2018;25(7-8):538-553. doi:10.1089/ten.tea.2018.0142. link

Li A, Wei Y, Hung CT, Vunjak-Novakovic G. Chondrogenic properties of collagen type XI, a component of cartilage extracellular matrix. Biomaterials. 2018 Aug;173:47-57. doi: 10.1016/j.biomaterials.2018.05.004. Epub 2018 May 3. link

Guo XE, Hung CT, Sandell LJ, Silva MJ: Musculoskeletal mechanobiology: A new era for MechanoMedicine. J Orthop Res 36(2):531-532, 2018. link

Estell EG, Murphy LA, Silverstein AM, Tan AR, Shah RP, Ateshian GA, Hung CT: Fibroblast-Like Synoviocyte Mechanosensitivity to Fluid Shear is Modulated by Interleukin-1α. Journal Biomech 60:91-99, 2017. link

Nims RJ, Cigan AD, Durney KM, Jones BK, O'Neill JD, Law WA, Vunjak-Novakovic G, Hung CT, Ateshian GA: Constrained Cage Culture Improves Engineered Cartilage Functional Properties by Enhancing Collagen Network Stability. Tissue Eng Part A 23(15-16):847-858, 2017. link

Silverstein AM, Stefani RM, Sobczak E, Tong EL, Attur MG, Shah RP, Bulinski JC, Ateshian GA, Hung CT: Toward Understanding the Role of Cartilage Particulates in Synovial Inflammation. Osteoarthritis Cartilage 25(8):1353-1361, 2017. link

Silverstein AM, Stoker AM, Ateshian GA, Bulinski JC, Cook JL, Hung CT: Transient expression of the diseased phenotype of osteoarthritic chondrocytes in engineered cartilage. J Orthop Res 35(4):829-836, 2017. link

Tan AR, Hung CT: Concise Review: Mesenchymal Stem Cells for Functional Cartilage Tissue Engineering: Taking Cues From Chondrocyte-Based Constructs. Stem Cells Transl Med 6(4):1295-1303, 2017.

Boushell MK, Hung CT, Hunziker EB, Strauss EJ, Lu HH: Current strategies for integrative cartilage repair. Connect Tissue Res 58(5):393-406, 2017. link

Cigan AD, Durney KM, Nims RJ, Vunjak-Novakovic G, Hung CT, Ateshian GA: Nutrient Channels Aid the Growth of Articular Surface-Sized Engineered Cartilage Constructs. Tissue Eng Part A 22(17-18):1063-74, 2016. link

Cigan AD, Nims RJ, Vunjak-Novakovic G, Hung CT, Ateshian GA: Optimizing nutrient channel spacing and revisiting TGF-beta in large engineered cartilage constructs. J Biomech 49(10):2089-94, 2016. link

Cigan AD, Roach BL, Nims RJ, Tan AR, Albro MB, Stoker AM, Cook JL, Vunjak-Novakovic G, Hung CT, Ateshian GA: High seeding density of human chondrocytes in agarose produces tissue-engineered cartilage approaching native mechanical and biochemical properties. J Biomech49(9):1909-17, 2016. link

Roach BL, Kelmendi-Doko A, Balutis EC, Marra KG, Ateshian GA, Hung CT: Dexamethasone Release from Within Engineered Cartilage as a Chondroprotective Strategy Against Interleukin-1α. Tissue Eng Part A 22(7-8):621-32, 2016. link

Nims RJ, Durney KM, Cigan AD, Dusséaux A, Hung CT, Ateshian GA: Continuum theory of fibrous tissue damage mechanics using bond kinetics: application to cartilage tissue engineering. Interface Focus 6(1):20150063, 2016. link

Jones B, Hung CT, Ateshian G: Biphasic analysis of cartilage stresses in the patellofemoral joint. J Knee Surg 29(2):92-8, 2016. link

Nover AB, Jones BK, Yu WT, Donovan DS, Podolnick JD, Cook JL, Ateshian GA, Hung CT. A Puzzle Assembly Strategy for Fabrication of Large Engineered Cartilage Tissue Constructs. J Biomech 49(5):668-77, 2016. link

Nover AB, Hou GY, Han Y, Wang S, O'Connell GD, Ateshian GA, Konofagou EE, Hung CT: High intensity focused ultrasound as a tool for tissue engineering: application to cartilage. Med Eng Phys 38:192-198, 2016. link

Hung CT, Ateshian GA: Grading of osteoarthritic cartilage: correlations between histology and biomechanics. J Orthop Res 34(10):8-9, 2016. link

Albro MB, Nims RJ, Durney KM, Cigan AD, Shim JJ, Vunjak-Novakovic G, Hung CT, Ateshian GA: Heterogeneous engineered cartilage growth results from gradients of media-supplemented active TGF-β and is ameliorated by the alternative supplementation of latent TGF-β. Biomaterials 77:173-85, 2016. link

Nover AB, Stefani RM, Lee SL, Ateshian GA, Stoker AM, Cook JL, Hung CT: Long-term storage and preservation of tissue engineered articular cartilage. J Orthop Res 34(10):141-8, 2016. link

Thompson CL, Patel R, Kelly TA, Wann AK, Hung CT, Chapple JP, Knight MM: Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by interleukin-1β. Arthritis Res Ther 17(1):373, 2015. link

Tan AR, VandenBerg CD, Attur M, Abramson SB, Knight MM, Bulinski JC, Ateshian GA, Cook JL, Hung CT: Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult. Arthritis Res Ther 17:361, 2015. link

Jones BK, Durney KM, Hung CT, Ateshian GA: The friction coefficient of shoulder joints remains remarkably low over 24h of loading. J Biomech 48(14):3945-9, 2015. link

Ponnurangam S, O'Connell GD, Hung CT, Somasundaran P: Biocompatibility of polysebacic anhydride microparticles with chondrocytes in engineered cartilage. Colloids Surf B Biointerfaces 136:207-13, 2015. link

Nover AB, Lee SL, Georgescu MS, Howard DR, Saunders RA, Yu WT, Klein RW, Napolitano AP, Ateshian GA, Hung CT: Porous titanium bases for osteochondral tissue engineering. Acta Biomater 27:286-93, 2015. link

Oungoulian SR, Durney KM, Jones BK, Ahmad CS, Hung CT, Ateshian GA: Wear and damage of articular cartilage with friction against orthopedic implant materials. J Biomech 48(10):1957-64, 2015. link

Roach BL, Hung CT, Cook JL, Ateshian GA, Tan AR: Fabrication of tissue engineered osteochondral grafts for restoring the articular surface of diarthrodial joints. Methods 84:103-8, 2015. link

Nims RJ, Cigan AD, Albro MB, Vunjak-Novakovic G, Hung CT, Ateshian GA: Matrix production in large engineered cartilage constructs is enhanced by nutrient channels and excess media supply. Tissue Eng Part C Methods 21(7):747-57, 2015. link

Cigan AD, Nims RJ, Albro MB, Vunjak-Novakovic G, Hung CT, Ateshian GA: Nutrient channels and stirring enhanced the composition and stiffness of large cartilage constructs. J Biomech 47(16):3847-54, 2015. link

O'Connell GD, Tan AR, Cui V, Bulinski JC, Cook JL, Attur M, Abramson SB, Ateshian GA, Hung CT: Human chondrocyte migration behaviour to guide the development of engineered cartilage. J Tissue Eng Regen Med [Epub ahead of print], 2015. link

Tan AR, Alegre-Aguarón E, O'Connell GD, VandenBerg CD, Aaron RK, Vunjak-Novakovic G, Chloe Bulinski J, Ateshian GA, Hung CT: Passage-dependent relationship between mesenchymal stem cell mobilization and chondrogenic potential. Osteoarthritis Cartilage 23(2):319-27, 2015. link

Cook JL, Stoker AM, Stannard JP, Kuroki K, Cook CR, Pfeiffer FM, Bozynski C, Hung CT: A novel system improves preservation of osteochondral allografts. Clin Orthop Relat Res 472(11):3404-14, 2014. link

Ponnurangam S, O'Connell GD, Chernyshova IV, Wood K, Hung CT, Somasundaran P: Beneficial effects of cerium oxide nanoparticles in development of chondrocyte-seeded hydrogel constructs and cellular response to interleukin insults. Tissue Eng Part A 20(21-22):2908-19, 2014. link

O'Connell GD, Nims RJ, Green J, Cigan AD, Ateshian GA, Hung CT: Time and dose-dependent effects of chondroitinase ABC on growth of engineered cartilage. Eur Cell Mater 27:312-20, 2014. link

Cook JL, Hung CT, Kuroki K, Stoker Am, Cook CR, Pfeiffer FM, Sherman SL, Stannard JP: Animal models of cartilage repair. Bone Joint Res 3(4):89-94, 2014. link

Alegre-Aguaron E, Sampat SR, Xiong JC, Colligan RM, Bulinski JC, Cook JL, Ateshian GA, Brown LM, Hung CT: Growth factor priming differentially modulates components of the extracellular matrix proteome in chondrocytes and synovium-derived stem cells. PLoS One 9(2):e88053, 2014. link

Oungoulian SR, Hehir KE, Zhu K, Willis CE, Marinescu AG, Merali N, Ahmad CS, Hung CT, Ateshian GA: Effect of glutaraldehyde fixation on the frictional response of immature bovine articular cartilage explants. J Biomech 47(3):694-701, 2014. link

Nims RJ, Cigan AD, Albro MB, Hung CT, Ateshian GA: Synthesis rates and binding kinetics of matrix products in engineered cartilage constructs using chondrocyte-seeded agarose gels. J Biomech 47(9):2165-72, 2014. link

Sampat SR, Dermksian MV, Oungouilan SR, Winchester RJ, Bulinski JC, Ateshian GA, Hung CT: Applied osmotic loading for promoting development of engineered cartilage. J Biomech 46(15):2674-81, 2013. link

Kelly TA, Roach BL, Weidner ZD, Mackenzie-Smith CR, O’Connell GD, Lima EG, Stoker AM, Cook JL, Ateshian GA, Hung CT: Tissue-engineered articular cartilage exhibits tension-compression nonlinearity reminiscent of native cartilage. J Biomech 46(11):1784-91, 2013. link

Cigan AD, Nims RJ, Albro MB, Esau JD, Dreyer MP, Vunjak-Novakovic G, Hung CT, Ateshian GA: Insulin, ascorbate, and glucose have a much great influence than transferrin and selenous acid on the in vitro growth of engineered cartilage in chondrogenic media. Tissue Eng Part A 19(17-18):1941-8, 2013. link

Oungoulian SR, Chang S, Bortz O, Hehir KE, Zhu K, Willis CE, Hung CT, Ateshian GA: Articular cartilage wear characterization with a particle sizing and counting analyzer. J Biomech Eng 135(2):024501, 2013. link

Albro MB, Nims RJ, Cigan AD, Yeroushalmi KJ, Shim JJ, Hung CT, Ateshian GA: Dynamic mechanical compression of devitalized articular cartilage does not activate latent TGF-beta. J Biomech 46(8):1433-9, 2013. link

Albro MB, Nims RJ, Cigan AD, Yeroushalmi KJ, Alliston T, Hung CT, Ateshian GA: Accumulation of exogenous activated TGF-beta in the superficial zone of articular cartilage. Biophys J 104(8):1794-804, 2013. link

Gunja NJ, Chen A, Dujari D, Luengo A, Fong JV, Hung CT: Migration response of outer and inner meniscus cells to applied direct current electric fields. J Orthop Res 30(1):103-11, 2012. link

O’Connell GD, Fong JV, Dunleavy N, Joffe A, Ateshian GA, Hung CT: Trimethylamine N-oxide as a media supplement for cartilage tissue engineering. J Orthop Res 30(12):1898-905, 2012. link

Albro MB, Cigan AD, Nims RJ, Yeroushalmi KJ, Oungoulian SR, Hung CT, Ateshian GA: Shearing of synovial fluid activates latent TGF-beta. Osteoarthritis Cartilage 20(11):1374-82, 2012. link

Lima EG, Durney KM, Sirsi SR, Nover AB, Ateshian GA, Borden MA, Hung CT: Microbubbles as biocompatible porogens for hydrogel scaffolds. Acta Biomater 8(12):4334-41, 2012. link

Ateshian GA, Morrison B 3rd, Holmes JW, Hung CT: Mechanics of Cell Growth. Mech Res Commun 42:118-125, 2012. link

Stoker A, Garrity JT, Hung CT, Stannard JW, Hung CT: Improved preservation of fresh osteochondral allografts for clinical use. J Knee Surg 25(2):117-25, 2012. link

O’Connell GD, Lima EG, Bian L, Chahine NO, Albro MB, Cook JL, Ateshian GA, Hung CT: Toward engineering a biological joint replacement. J Knee Surg 25(3):187-96, 2012. link

Tan AR, Dong EY, Andry JP, Bulinsk JC, Ateshian GA, Hung CT: Co-culture of engineered cartilage with freshly harvested primary chondrocytes induces expedited growth. Clin Orthop 469(10):2735-2743, 2011. link

Hung CT, Cook JL: Clinically relevant strategies for treating cartilage and meniscal pathology: editorial comment. Clin Orthop Rel Res 469(10):2677-2678, 2011. link

Jayabalan P, Tan AR, Rahaman MN, Bal S, Hung CT, Hung CT, Cook JL: Bioactive glass 13-93 as a subchondral substrate for tissue-engineered osteochondral constructs- A Pilot Study. Clin Orthop 469(10):2735-43. link

Ateshian GA: The role of mass balance equations in growth mechanics illustrated in surface and volume dissolution. J Biomech Eng 2011. link

Albro MB, Banerjee RE, Li R, Oungoulian SR, Chen B, Del Palomar AP, Hung CT, Ateshian GA: Dynamic loading of immature epiphyseal cartilage pumps nutrients out of vascular canals. J Biomech 44(9):1654-1659, 2011. link

Sampat SR, O’Connell GD, Fong JV, Aguaron EA, Ateshian GA, Hung CT. Synovium derived stem cells for cartilage tissue engineering. Tissue Eng Part A, 17(17-18):2259-2265, 2011. link

Oswald ES, Brown LM, Bulinski JC, Hung CT: Label-free protein profiling of adipose-derived human stem cells under hyperosmotic treatment. J Proteome Res 10(7):3050-3059, 2011. link

Ng KW, O’Conor CJ, Kugler LE, Cook JL, Ateshian GA, Hung CT: Transient supplementation of anabolic growth factors rapidly stimulates matrix synthesis in engineered cartilage. Ann Biomed Eng 39(10):2491-2500, 2011. link

Oswald ES, Ahmed HS, Kramer SP, Bulinski JC, Ateshian GA, Hung CT: Effects of hypertonic (NaCl) two-dimensional and three-dimensional culture conditions on the properties of cartilage tissue engineered from an expanded mature bovine chondrocyte source. Tissue Eng C 17(11):1041-9, 2011. link

Bian L, Stoker AM, Marberry KM, Ateshian GA, Cook JL, Hung CT: Effects of Dexamethasone on the Functional Properties of Cartilage Explants during Long-term Culture. Am J Sports Med 38(1):78-85, 2010. link

Ng KW, Lima EG, Bian L, O’Conor CJ, Jayabalan PS, Stoker AM, Kuroki K, Cook CR, Ateshian GA, Cook JL, Hung CT: Passaged adult chondrocytes can form engineered cartilage with functional membrane properties: A canine model. Tissue Engineering A 16(3):1041-1051, 2010. link

Bian L, Fong JV, Lima EG, Stoker AM, Ateshian GA, Cook JL, Hung CT: Dynamic mechanical loading enhances functional properties of tissue engineered cartilage using mature canine chondrocytes. Tissue Engineering Part A 16(5):1781-1790, 2010. link

Grayson WL, Bhumiratana S, Chao GPH, Hung CT, Vunjak-Novakovic G: Spatial regulation of human mesenchymal stem cell differentiation in engineered osteochondral constructs: effects of pre-differentiation, soluble factors and medium perfusion. Osteoarthritis Cartilage 18(5):714-723, 2010. link

Guterl CC, Hung CT, Ateshian GA: Electrostatic and non-electrostatic contributions of proteoglycans to the compressive equilibrium modulus of bovine articular cartilage. J Biomech 43(7):1343-1350, 2010. link

Ateshian GA, Morrison B 3rd, Hung CT: Modeling of active transmembrane transport in a mixture theory framework. Ann Biomed Eng 38(5):1801-1814, 2010. link

Jiang J, Tang A, Ateshian GA, Guo XE, Hung CT, Lu HH: Bioactive stratified polymer ceramic-hydrogel scaffold for integrative osteochondral repair. Ann Biomed Eng 38(6):2183-2196, 2010. link

Albro MB, Li R, Banerjee RE, Hung CT, Ateshian GA: Validation of theoretical framework explaining active solute uptake in dynamically loaded porous media. J Biomech 2010 Aug 26; 43(12):2267-7, 2010. link

Hung CT: Transient receptor potential vanilloid 4 channel as an important modulator of chondrocyte mechanotransduction of osmotic loading. Arthritis Rheum 62(10):2850-1, 2010. link

Tan AR, Dong EY, Ateshian GA, Hung CT: Response of engineered cartilage to mechanical insult depends on construct maturity. Osteoarthritis Cartilage 18(12):1577-1585, 2010. link

Kelly TN, Ng KW, Ateshian GA, Hung CT: Analysis of radial variations in material properties and matrix composition of chondrocyte-seeded agarose hydrogel constructs. Osteoarthritis Cartilage 17(1):73-82, 2009. link

Ng KW, Kugler LE, Doty SB, Ateshian GA, Hung CT: Scaffold degradation elevates the collagen content and dynamic compressive modulus in engineered articular cartilage. Osteoarthritis Cartilage 17(2):220-227, 2009. link

Lima EG, Tan AR, Tai T, Marra KG, DeFail A, Ateshian GA, Hung CT: Genipin enhances the mechanical properties of tissue engineered cartilage and projects against inflammatory degradation when used as a medium supplement. J Biomed Mater Res A 91(3):692-700, 2009. link

Bian L, Angione SL, Ng KW, Williams DY, Mao DQ, Ateshian GA, Hung CT: Influence of decreasing nutrient path length on the development of engineered cartilage. Osteoarthritis Cartilage 17(5):677-685, 2009. link

Bian L, Kaplun M, Williams DY, Xu D, Ateshian GA, Hung CT: Influence of chondroitin sulfate on the biochemical and mechanical properties of cartilage explants in long term culture. J Biomechanics 42(3):286-90, 2009. link

Chahine NO, Albro BM, Lima EG, Wei VI, Dubois CR, Hung CT, Ateshian GA: Effect of dynamic loading on the transport of solutes into agarose hydrogels. Biophys J 97(4):968-975, 2009. link

Bian L, Crivello K, Ng KW, Xu D, Williams DY, Ateshian GA, Hung CT: Influence of temporary chondroitinase ABC-induced GAG suppression on maturation of tissue engineered cartilage. Tissue Engineering 15(8):2065-2072, 2009. link

Ng KW, Ateshian GA, Hung CT: Zonal chondrocytes seeded in a layered agarose hydrogel create engineered cartilage with depth-dependent cellular and mechanical inhomogeneity. Tissue Engineering 15(9):2315-2324, 2009. link

Hung CT: One breath closer to making engineered tissues a clinical reality. Cell Stem Cell 4(1):5-6, 2009. link

Guterl CC, Gardner TR, Rajan V, Ahmad CS, Hung CT, Ateshian GA: Two-Dimensional Strain Fields on the Cross-Section of the Human Patellofemoral Joint under Physiological Loading. Biomechanics 41(15):3145-3151, 2009. link

Ateshian GA, Costa KD, Azeloglu EU, Morrison III B, Hung CT: Continuum modeling of biological tissue growth by cell division, and alteration of intracellular osmolytes and extracellular fixed charge density. J Biomech Eng 131(10):101001, 2009. link

Ateshian GA, Rajan V, Chahine NO, Canal CE, Hung CT: Modeling the matrix of articular cartilage using a continuous fiber angular distribution predicts many observed phenomena. J Biomech 131(6):061003, 2009. link

Ng KW, Mauck RL, Wang CCB, Kelly TN, Ho MMY, Chen FH, Ateshian GA, Hung CT: Duty cycle of deformational loading influences the growth of engineered articular cartilage. Cell Mol Bioeng 2(3): 386-394, 2009. link

Albro M, Rajan V, Li R, Hung CT, Ateshian GA: Characterization of the concentration-dependence of solute diffusivity and portioning in a model dextran-agarose transport system. Cell Mol Bioeng 2(3):295-305, 2009. link

Albro M, Petersen LE, Li R, Hung CT, Ateshian GA: Influence of partitioning of osmolytes by the cytoplasm on the passive response of cells to osmotic loading. Biophys J, 97(11):2886-93, 2009. link

Ng KW, DeFrancis JG, Kugler LE, Kelly TN, Ho MM, O’Conor CJ, Ateshian GA, Hung CT: Amino acids supply in culture media is not a limiting factor in the matrix synthesis of engineered cartilage tissue. Amino Acids 35(2):433-438, 2008. link

Kelly TN, Fisher MB, Oswald ES, Tai T, Mauck RL, Ateshian GA, Hung CT: Low-serum media and dynamic deformational loading in tissue engineering of articular cartilage. Ann Biomed Eng 36(5):769-779, 2008. link

Bian LM, Lima EG, Angione SL, Ng KW, Williams DY, Xu D, Stoker AM, Cook JL, Ateshian GA, Hung CT: Mechanical and biochemical characterization of cartilage explants in serum-free culture. J Biomechanics 41(6):1153-1159, 2008. link

Lima EG, Tan AR, Tai T, Bian L, Stoker AM, Ateshian GA, Cook JL, Hung CT: Differences in interleukin-1 response between engineered and native cartilage. Tissue Eng 14(10):1721-1730, 2008. link

Huo B, Lu XL, Hung CT, Costa KD, Xu Q, Whitesides GM, Guo XE: Fluid flow induced calcium response in bone cell network. Cell Mol Bioeng 1(1):58-66, 2008. link

Moffat KL, Sun W-H S, Pena PE, Chahine NO, Doty SB, Ateshian GA, Hung CT, Lu HH: Characterization of the compressive mechanical properties and mineral distribution at the ligament-to-bone insertion site. Proc Natl Acad Sciences 105(23):7947-7952, 2008. link

Lima EG, Chao PG, Ateshian GA, Bal S, Cook JL, Vunjak-Novakovic G, Hung CT : The effect of devitalized trabecular bone on the formation of osteochondral tissue-engineered constructs. Biomaterials 29(32):4292-4299, 2008. link

Lima EG, Tan AR, Tai T, Bian L, Ateshian GA, Cook JL, Hung CT: Physiologic deformational loading does not counteract the catabolic effects of interleukin-1 in long-term culture of chondrocyte-seeded agarose constructs. J Biomechanics 41(15):3253-3259, 2008. link

Albro MB, Chahine NO, Li R, Yeager K, Hung CT, Ateshian GA: Dynamic loading of deformable porous media can induce active solute transport. J Biomechanics, 41(15):3152-3157, 2008. link

Canal CE, Hung CT, Ateshian GA: Two-Dimensional Strain Fields on the Cross-Section of the Bovine Humeral Head Under Contact Loading. J Biomechanics 41(15):3145-3151, 2008. link

Oswald ES, Chao PG, Bulinski JC, Ateshian GA, Hung CT: Dependence of zonal chondrocyte water transport properties on osmotic environment. Cell Mol Bioeng 1(4):339-348, 2008. link

Ateshian GA, Costa KD, Hung CT: A theoretical analysis of water transport through chondrocytes. Biomech Model Mechanobiol 6(1-2):91-101, 2007.

Chahine NO, Ateshian GA, Hung CT: The effect of finite compressive strain on chondrocyte viability in statically loaded bovine articular cartilage. Biomech Model Mechanobiol 6(1-2):103-111, 2007.

Basalo IM, Chahine NO, Kaplun M, Chen FH, Hung CT, Ateshian GA: Chondroitin sulfate reduces the friction coefficient of articular cartilage. J Biomechanics 40(8):1847-1854, 2007. link

Guo XE, Takai E, Jiang XJ, Xu Q, Whitesides GM, Yardley JT, Hung CT, Chow E, Hantschel T, Costa KD: Intracellular calcium waves in bone cell networks under single cell nanoindentation. Mol Cell Biomech 3(3):95-107, 2007.

Lima EG, Bian L, Ng KW, Mauck RL, Byers BA, Tuan RS, Ateshian GA, Hung CT: The beneficial effect of delayed compressive loading on tissue-engineered cartilage constructs cultured with TGF-beta3. Osteoarthritis Cartilage 15(9): 1025-1033, 2007. link

Chahine NO, Hung CT, Ateshian GA: In situ measurements of chondrocyte deformation under transient loading. Eur Cell Mater 13:100-111, 2007. link

Chao PG, Lu HH, Hung CT*, Nicoll SB, Bulinski JC: Effects of applied DC electric field on ligament fibroblast migration and wound healing. Connect Tissue Res 48(4):188-197, 2007. (*corresponding author) link

Albro MB, Chahine NO, Caligaris M, Wei VI, Likhitpanichkul M, Ng KW, Hung CT, Ateshian GA: Osmotic loading of spherical gels: a biomimetic study of hindered transport in the cell protoplasm. J Biomech Eng 129(4):503-510, 2007. link

Finkelstein EI, Chao PH, Hung CT, Bulinski JC: Electric field-induced polarization of charged cell surface proteins does not determine the direction of galvanotaxis. Cell Motil Cytoskeleton 64(11):833-846, 2007. link

Ng KW, Saliman JD, Lin EY, Statman LY, Kugler LE, Lo SB, Ateshian GA, Hung CT: Culture duration modulates collagen hydrolysate-induced tissue remodeling in chondrocyte-seeded agarose hydrogels. Ann Biomed Eng 35(11):1914-1923, 2007. link

Lima EG, Bian L, Mauck RL, Byers BA, Tuan RS, Ateshian GA, Hung CT: The effect of applied compressive loading on tissue-engineered cartilage constructs cultured with TGF-beta3. Conf Proc IEEE Eng Med Biol Soc 1:779-82, 2006. link

Oswald ES, Chao PH, Bulinski JC, Ateshian GA, Hung CT: Chondrocyte nuclear response to osmotic loading. Conf Proc IEEE Eng Med Biol Soc 1:3659-61, 2006. link

Moffat KL, Sun WH, Chahine NO, Pena PE, Doty SB, Hung CT, Ateshian GA, Lu HH: Characterization of the mechanical properties and mineral distribution of the anterior cruciate ligament-to-bone insertion site. Conf Proc IEEE Eng Med Biol Soc 1:2366-9, 2006. link

Kelly TN, Ng KW, Wang CCB, Ateshian GA, Hung CT: Spatial and temporal development of chondrocyte-seeded agarose constructs in free-swelling and dynamically loaded cultures. J Biomechanics 39(8):1489-1497, 2006. link

Ateshian GA, Likhitpanichkul M, Hung CT: A mixture theory analysis of passive transport in osmotic loading of cells. J Biomechanics 39(3):464-75, 2006. link

Basalo IM, Chen FH, Hung CT, Ateshian GA: Frictional response of bovine articular cartilage under creep loading following proteoglycan digestion with chondroitinase ABC. J Biomech Eng 128(1):131-134, 2006. link

Takai E, Landesberg R, Katz RW, Hung CT, Guo XE: Substrate modulation of osteoblast adhesion strength, focal adhesion kinase activation, and responsiveness to mechanical stimuli. Mol Cell Biomech. 3(1):1-12, 2006. link

Guo XE, Takai E, Jiang X, Xu Q, Whitesides GM, Yardley JT, Hung CT, Chow EM, Hantschel T, Costa KD: Intracellular calcium waves in bone cell networks under single cell nanoindentation. Mol Cell Biomech 3(3):95-107, 2006. link

Ishii Y, Thomas AO, Guo XE, Hung CT, Chen FH: Localization and distribution of Cartilage Oligomeric Matrix Protein in the rat intervertebral disc. Spine 31(14):1539-1546, 2006. link

Ng KW, Mauck RL, Statman LY, Lin EY, Ateshian GA, Hung CT: Dynamic deformational loading results in selective application of mechanical stimulation in a layered, tissue-engineered construct. Biorheology 43(3-4): 497-507, 2006. link

Ho MH, Kelly TN, Guo XE, Ateshian GA, Hung CT: Spatially varying material properties of the rat intervertebral disc. Spine 31(15):E486-93, 2006. link

Chao PHG, West AC, Hung CT: Chondrocyte intracellular calcium, cytoskeletal organization and gene expression responses to dynamic osmotic loading. Am J Physiol (Cell Physiology) 291(4):C718-25, 2006. link

Ateshian GA and Hung CT: The natural synovial joint: properties of cartilage. J Eng Tribology 220(J8):657-670. link

Ng KW, Wang CC-B, Mauck RL, Kelly TN, Chahine NO, Costa KD, Ateshian GA, Hung CT: A layered agarose approach to fabricate depth-dependent inhomogeneity in chondrocyte-seeded constructs. J Orthop Res 23(1), 134-141,2005. link

Chao PHG, Tang Z, Angelini E, West AC, Costa KD, Hung CT: Dynamic osmotic loading of cells using a novel microfluidic device. J Biomechanics 38(6), 1273-1281, 2005. link

Basalo IM, Raj D, Krishnan R, Chen FH, Hung CT, Ateshian GA: Effects of enzymatic degradation on the frictional response of articular cartilage in stress relaxation. J Biomechanics 38(6), 1343-1349, 2005. link

Takai E, Costa KD, Shaheen A, Hung CT, Guo XE: Osteoblast elastic modulus measured by atomic force microscopy is substrate dependent, Ann Biomed Eng, 33(7), 963-971, 2005. link

Gupta R, Truong L, Bear D, Chafik D, Modafferi E, Hung CT: Shear stress alters the expression of Myelin Associated Glycoprotein (MAG) and Myelin Basic Protein (MBP) in Schwann cells. J Orthop Res 23(5), 1232-9, 2005. link

Chahine NO, FH Chen, Hung CT, Ateshian GA: Direct Measurement of Osmotic Pressure of glycosaminoglycan solutions by membrane osmometry at room temperature. Biophysical Journal 89(3),1543-50, 2005. link

Ateshian GA and Hung CT: Patellofemoral joint biomechanics and tissue engineering. Clin Orthop Res Relat Res 436:81-90, 2005. link

Park S, Hung CT, Ateshian GA: Mechanical response of bovine articular cartilage under dynamic unconfined compression loading at physiologic stress levels. Osteoarthritis Cartilage, 12(1):65-73, 2004. link

Ateshian GA, Chahine NO, Basalo IM, Hung CT: The correspondence between equilibrium biphasic and triphasic material properties in mixture models of articular cartilage. J Biomechanics 37, 391-400, 2004. link

Hung CT, Mauck RL, Wang CC-B, Lima EG, Ateshian GA: A paradigm for functional tissue engineering of articular cartilage via applied physiologic deformational loading. Ann Biomed Eng 32(1), 35-49, 2004. link

Finkelstein E, Chang W, Chao PHG, Gruber D, Hung CT, Bulinski C: Roles of microtubules, cell polarity, and adhesion in electric field-mediated motility. J Cell Science 117(8),1533-1545, 2004. link

Chahine NO, Wang CC-B, Hung CT, Ateshian GA: Anisotropic strain-dependent material properties of bovine articular cartilage in the transitional range from tension to compression. J Biomechanics 37, 1251-1261, 2004. link

Kelly TN, Wang CC-B, Mauck RL, Ateshian GA, Hung CT: Role of cell-associated matrix on material development of free-swelling and dynamically loaded chondrocyte-seeded agarose gels. Biorheology, 41, 223-237, 2004. link

Lima EG, Mauck RL, Han S, Park S, Ng KW, Ateshian GA, Hung CT: Functional tissue engineering of chondral and osteochondral constructs. Biorheology 41, 577-590, 2004. link

Takai E, Mauck RL, Hung CT, Guo XE: Osteocyte viability and regulation of osteoblast function in a 3D trabecular bone explant under dynamic hydrostatic pressure. J Bone Min Res 19(9):1403-1410, 2004. link

Basalo IM, Mauck RL, Kelly TN, Nicoll SB, Chen FH, Hung CT, Ateshian GA: Cartilage interstitial fluid load support in unconfined compression following enzymatic digestion. J Biomechanics 126, 779-786, 2004. link

Krishnan R, Caligaris M, Mauck RL, Hung CT, Costa KD, Ateshian GA: Removal of the superficial zone of articular cartilage does not increase its frictional coefficient. Osteoarthritis Cartilage 12(12), 947-955, 2004. link

Lu HH, Jiang J, Tang A, Hung CT, Guo XE: Development of controlled heterogeneity on a polymer-ceramic hydrogel scaffold for osteochondral repair. Bioceramics, 17:609-613, 2004.

Chafik D, Bear D, Bui P, Patel A, Jones NF, Kim BT, Hung CT, Gupta R, Optimization of schwann cell adhesion in response to shear stress in an in vitro model for peripheral nerve tissue engineering. Tissue Eng 9(2):233-241, 2003. link

Ateshian GA, Soltz MA, Mauck RL, Hung CT, Lai WM: The role of osmotic pressure in the frictional response of articular cartilage. Transport Porous Media 50:5-33,2003.

Hung CT, LeRoux MA. Palmer GD, Chao PG, Valhmu WB: Disparate aggrecan gene expression in chondrocytes subjected to hypotonic and hypertonic loading in 2D and 3D culture. Biorheology 40(1-3): 61-72, 2003. link

Wang CCB, Chahine NO, Hung CT, Ateshian GA: Optical determination of anisotropic material properties of bovine articular cartilage in compression, J Biomechanics 36(3): 339-353, 2003. link

Mauck RL, Nicoll SB, Seyhan SL, Ateshian GA, Hung CT: Synergistic effects of growth factors and dynamic loading for cartilage tissue engineering. Tissue Eng 9(4), 597-611, 2003. link

Mauck RL, Hung CT, Ateshian GA: Modeling of neutral solute transport in a dynamically loaded porous permeable gel. J Biomech Eng 125(5): 602-614, 2003. link

Hung CT, Lima EG, Mauck RL, Takai E, LeRoux MA, Lu HH, Stark RG, Guo XE, Ateshian GA: Anatomically shaped osteochondral constructs for articular cartilage repair. J Biomechanics 36(12): 1853-1864, 2003. link

Mauck RL, Wang CC-B, Oswald ES, Ateshian GA, Hung CT: The role of cell seeding density and nutrient supply for articular cartilage tissue engineering with deformational loading. Osteoarthritis Cartilage 11(12): 879-890, 2003. link

Morrison III B, Cater HL, Wang CC-B, Thomas FC, Hung CT, Ateshian GA, Sundstrom LE: A tissue level tolerance criterion for living brain developed with an in vitro model of traumatic mechanical loading. Stapp Car Crash Journal 47: 93-105, 2003. link

Wang CC-B, Guo, XE, Sun, D, Mow VC, Ateshian GA, Hung CT: The functional environment of chondrocytes within cartilage subjected to compressive loading: theoretical and experimental approach. Biorheology, 39(1-2):39-45, 2002. link

Wang CC-B, Ateshian GA, Hung CT: An automated approach for direct measurement of strain distributions within articular cartilage under unconfined compression. J Biomech Eng 124:557-567,2002. link

Mauck RL, Seyhan SL, Ateshian GA, Hung CT: The influence of seeding density and dynamic deformational loading on the developing structure/function relationships of chondrocyte-seeded agarose hydrogels. Ann Biomed Eng 30:1046-1056, 2002. link

Wang CC-B, Hung CT, Mow VC: An analysis of the effects of depth-dependent aggregate modulus on articular cartilage stress-relaxation behavior in compression. J Biomechanics 34(1): 75-84, 2001. link

Palmer GD, Chao P-HG, Raia F, Mauck RL, Valhmu WB, Hung CT: Time dependent aggrecan gene expression of articular chondrocytes subjected to hyperosmotic loading. Osteoarthritis Cartilage 9(8): 761-770, 2001. link

Hung CT, Henshaw DR, Wang CC-B, Mauck R, Raia F, Palmer G, Mow VC, Ratcliffe A, Valhmu WB: Mitogen-activated protein kinase signaling in bovine articular chondrocytes in response to fluid flow does not require calcium mobilization. J Biomechanics 33:73-80, 2000. link

Chao P-HG, Roy R, Mauck RL, Liu W, Valhmu WB, Hung CT: Chondrocyte translocation response to direct current electric fields. J Biomech Eng 122:261-267, 2000. link

Mauck RL, Soltz MA, Wang CC-B, Wong DD, Chao P-HG, Valhmu WB, Hung, CT, Ateshian GA: Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels. J Biomech Eng 122:252-260, 2000. link