Education

B.S.E, Bioengineering, Materials Science and Engineering, 2007, University of Pennsylvania
M.S., Biomedical Engineering, 2009, Columbia University
Ph.D., Biomedical Engineering, 2014, Columbia University

Curriculum Vitae

Awards

• Hung-Huang Graduate Award in Biomedical Engineering
• Tau Beta Pi
• NSF Graduate Fellowship

Areas of Research Interest

Tissue engineering; translational research; cartilage injury models; cell migration; mechano-chemical preconditioning

Background

Andrea joined the Cellular Engineering Laboratory in 2007. Having spent much of her undergraduate research career studying spine pain and meniscal repair strategies at the University of Pennsylvania, she has continued her research at Columbia in orthopaedics engineering and has furthered the lab’s efforts in understanding cartilage injury modalities and repair mechanisms, with many studies centered at the interface of bioengineering and cell biology. Andrea’s doctoral thesis focused on the role of cell migration and mechano-chemical preconditioning in the reparative response of tissue-engineered cartilage to mechanical injury and inflammatory cues, for which she received the Hung-Huang Graduate Award in Biomedical Engineering.

Since her graduation, Andrea has continued in the lab to help translate projects associated with her dissertation toward the clinical arena as a postdoctoral fellow. As such, she has been instrumental in securing funding through the Coulter Foundation Partnership with Columbia University to commercialize engineered osteochondral constructs for cartilage repair. In addition, her research on electric-field induced cell migration has led to a grant from the DOD aimed at treating osteoarthritis.

Selected Publications

1. Estell EG, Murphy LA, Silverstein AM, Tan AR, Shah RP, Ateshian GA, Hung CT. "Fibroblast-Like Synoviocyte Mechanosensitivity to Fluid Shear is Modulated by Interleukin-1α." Journal Biomech. [Epub ahead of print], 2017.
2. Tan AR and Hung CT: Concise Review: Mesenchymal Stem Cells for Functional Cartilage Tissue Engineering: Taking Cues From Chondrocyte-Based Constructs. Stem Cells Transl Med 6(4):1295-1303, 2017.
3. Cigan AD, Roach BL, Nims RJ, Tan AR, Albro MB, Stoker AM, Cook JL, Vunjak-Novakovic G, Hung CT, Ateshian GA: High seeding density of human chondrocytes in agarose produces tissue-engineered cartilage approaching native mechanical and biochemical properties. J Biomech49(9):1909-17, 2016.
4. Tan AR, VandenBerg CD, Attur M, Abramson SB, Knight MM, Bulinski JC, Ateshian GA, Cook JL, Hung CT: Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult. Arthritis Res Ther 17:361, 2015.
5. Roach BL, Hung CT, Cook JL, Ateshian GA, Tan AR: Fabrication of tissue engineered osteochondral grafts for restoring the articular surface of diarthrodial joints. Methods 84:103-8, 2015.
6. O'Connell GD*, Tan AR*, Cui V, Bulinski JC, Cook JL, Attur M, Abramson SB, Ateshian GA, Hung CT: Human chondrocyte migration behaviour to guide the development of engineered cartilage. J Tissue Eng Regen Med 2015 [Epub ahead of print].
7. Tan AR, Alegre-Aguarón E, O'Connell GD, VandenBerg CD, Aaron RK, Vunjak-Novakovic G, Chloe Bulinski J, Ateshian GA, Hung CT: Passage-dependent relationship between mesenchymal stem cell mobilization and chondrogenic potential. Osteoarthritis Cartilage 23(2):319-27, 2015. 
8. Tan AR & Hung CT (2011): Engineering Functional Cartilage Grafts. In H.S. Bernstein, Tissue Engineering in Regenerative Medicine (p. 237-250). New York: Springer.
9. Jayabalan P, Tan AR, Rahaman MN, Bal BS, Hung CT, Cook JL: Bioactive glass 13-93 as a subchondral substrate for tissue-engineered osteochondral constructs: a pilot study. Clin Orthop Relat Res 469(10):2754-63, 2011.
10. Tan AR, Dong EY, Andry JP, Bulinski JC, Ateshian GA, Hung CT: Coculture of engineered cartilage with primary chondrocytes induces expedited growth. Clin Orthop Relat Res 469(10):2735-43, 2011.
11. Tan AR, Dong EY, Ateshian GA, Hung CT: Response of engineered cartilage to mechanical insult depends on construct maturity. Osteoarthritis Cartilage 18(12):1577-85, 2010.
12. Lima EG, Tan AR, Tai T, Marra KG, DeFail A, Ateshian GA, Hung CT: Genipin enhances the mechanical properties of tissue-engineered cartilage and protects against inflammatory degradation when used as a medium supplement. J Biomed Mater Res A 91(3):692-700, 2009.
13. Lima EG, Tan AR, Tai T, Bian L, Ateshian GA, Cook JL, Hung CT: Physiologic deformational loading does not counteract the catabolic effects of interleukin-1 in long-term culture of chondrocyte-seeded agarose constructs. J Biomech 41(15):3253-9, 2008.
14. Lima EG, Tan AR, Tai T, Bian L, Stoker AM, Ateshian GA, Cook JL, Hung CT: Differences in interleukin-1 response between engineered and native cartilage. Tissue Eng Part A 14(10):1721-30, 2008.